CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03070
Pert ID:	BRD-K59332007
Compound Name:	linopirdine
Targets:	KCNQ2\|KCNQ3\|KCNQ4\|KCNQ5
MoA:	potassium channel blocker
SMILES:	O=C1N(c2ccccc2C1(Cc1ccncc1)Cc1ccncc1)c1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6899	BRD-K59332007	A375	10 uM	6 h	-0.22	-0.9	0.05	-0.34	-1.14	1.01
7473	BRD-K59332007	HA1E	10 uM	6 h	0.0	0.0	0.0	0.27	0.95	0.32
22311	BRD-K59332007	A549	10 uM	6 h	-0.35	-1.44	1.43	0.0	0.0	0.0
22805	BRD-K59332007	HCC515	10 uM	6 h	-0.23	-0.95	0.09	-0.35	-1.17	1.11
23102	BRD-K59332007	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
24329	BRD-K59332007	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
123913	BRD-K59332007	HEK293	0.125 uM	24 h	0.0	0.0	0.0	-0.36	-1.21	1.24
124014	BRD-K59332007	JURKAT	0.37 uM	24 h	0.25	1.06	0.18	-0.37	-1.25	1.35
124067	BRD-K59332007	MCF10A	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124134	BRD-K59332007	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124196	BRD-K59332007	THP1	0.125 uM	24 h	0.23	0.98	0.09	0.29	1.01	0.44
124248	BRD-K59332007	YAPC	0.37 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.46
132201	BRD-K59332007	HELA	0.08 uM	24 h	0.0	0.0	0.0	0.32	1.14	0.85
132237	BRD-K59332007	HT29	0.08 uM	24 h	0.0	0.0	0.0	-0.24	-0.82	0.14
132261	BRD-K59332007	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132305	BRD-K59332007	PC3	0.01 uM	24 h	0.0	0.0	0.0	0.24	0.86	0.15

Summary