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CMap Candidate Details

Structure:
CMap ID: C03072
Pert ID: BRD-K86118762
Compound Name: linsitinib
Targets: IGF1R|INSR|INSRR
MoA: IGF-1 inhibitor
SMILES: C[C@@]1(O)C[C@@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
116380 BRD-K86118762 HA1E 10 uM 24 h -0.22 -0.93 0.07 -0.36 -1.2 1.18
116429 BRD-K86118762 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
116481 BRD-K86118762 HEPG2 10 uM 24 h 0.28 1.18 0.39 -0.26 -0.87 0.23
116531 BRD-K86118762 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116577 BRD-K86118762 MCF??7.00 1.11 uM 24 h 0.27 1.11 0.26 0.28 0.98 0.37
125573 BRD-K86118762 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125610 BRD-K86118762 A549 3.33 uM 24 h -0.23 -0.97 0.11 -0.24 -0.81 0.12
125644 BRD-K86118762 HEK293 0.125 uM 24 h 0.3 1.25 0.54 0.0 0.0 0.0
125722 BRD-K86118762 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.26
125769 BRD-K86118762 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
125797 BRD-K86118762 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
125868 BRD-K86118762 PC3 10 uM 24 h 0.0 0.0 0.0 -0.49 -1.63 15.65
125921 BRD-K86118762 YAPC 3.33 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.71
133757 BRD-K86118762 HELA 0.25 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
133906 BRD-K86118762 MDAMB231 0.74 uM 24 h -0.26 -1.09 0.33 0.0 0.0 0.0
133970 BRD-K86118762 THP1 0.01 uM 24 h 0.0 0.0 0.0 -0.43 -1.46 15.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).