CMap Candidate Details
Structure:
| CMap ID: | C00308 |
| Pert ID: | BRD-K02265150 |
| Compound Name: | amoxapine |
| Targets: | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|HRH1|HRH4|HTR1A|HTR1B|HTR2A|HTR2B|HTR2C|HTR3A|HTR6|HTR7|SLC6A2|SLC6A3|SLC6A4 |
| MoA: | norepinephrine reputake inhibitor |
| SMILES: | Clc1ccc2Oc3ccccc3N=C(N3CCNCC3)c2c1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 5749 | BRD-K02265150 | HCC515 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.32 | 1.14 | 0.87 |
| 6508 | BRD-K02265150 | VCAP | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 42258 | BRD-K02265150 | ASC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 42594 | BRD-K02265150 | HEPG2 | 10 uM | 6 h | -0.27 | -1.14 | 0.42 | 0.28 | 0.99 | 0.4 |
| 43454 | BRD-K02265150 | NPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 43761 | BRD-K02265150 | PHH | 10 uM | 24 h | 0.22 | 0.92 | 0.04 | -0.24 | -0.82 | 0.15 |
| 91014 | BRD-K02265150 | HUH7 | 10 uM | 72 h | 0.18 | 0.73 | 0.0 | 0.28 | 0.99 | 0.39 |
| 122861 | BRD-K02265150 | HA1E | 0.04 uM | 24 h | 0.25 | 1.03 | 0.13 | 0.26 | 0.92 | 0.25 |
| 122899 | BRD-K02265150 | HEK293 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.28 | 0.99 | 0.4 |
| 122941 | BRD-K02265150 | HELA | 1.11 uM | 24 h | -0.28 | -1.15 | 0.44 | 0.0 | 0.0 | 0.0 |
| 122975 | BRD-K02265150 | HT29 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123024 | BRD-K02265150 | JURKAT | 10 uM | 24 h | 0.24 | 1.0 | 0.1 | 0.0 | 0.0 | 0.0 |
| 123114 | BRD-K02265150 | MDAMB231 | 10 uM | 24 h | 0.3 | 1.24 | 0.53 | -0.26 | -0.87 | 0.23 |
| 123147 | BRD-K02265150 | PC3 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123185 | BRD-K02265150 | THP1 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.98 | 0.48 |
| 123217 | BRD-K02265150 | YAPC | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.27 | -0.9 | 0.29 |
| 131211 | BRD-K02265150 | A375 | 0.74 uM | 24 h | -0.33 | -1.36 | 1.07 | 0.0 | 0.0 | 0.0 |
| 131247 | BRD-K02265150 | A549 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.3 | -1.01 | 0.58 |
| 131361 | BRD-K02265150 | HUVEC | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131401 | BRD-K02265150 | MCF10A | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131439 | BRD-K02265150 | MCF??7.00 | 0.74 uM | 24 h | -0.25 | -1.03 | 0.2 | -0.36 | -1.21 | 1.24 |