CMap Candidate Details
Structure:
| CMap ID: | C03105 |
| Pert ID: | BRD-K41599323 |
| Compound Name: | lonafarnib |
| Targets: | FNTA|HRAS|KRAS|NRAS |
| MoA: | farnesyltransferase inhibitor |
| SMILES: | NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 90853 | BRD-K41599323 | MCF10A | 10 uM | 12 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 95545 | BRD-K41599323 | A549 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 95633 | BRD-K41599323 | U2OS | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123550 | BRD-K41599323 | HA1E | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123604 | BRD-K41599323 | HEK293 | 0.125 uM | 24 h | 0.18 | 0.77 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123669 | BRD-K41599323 | HT29 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.27 | 0.94 | 0.3 |
| 123736 | BRD-K41599323 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123780 | BRD-K41599323 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.22 | 0.78 | 0.07 |
| 132001 | BRD-K41599323 | A375 | 0.74 uM | 24 h | 0.27 | 1.13 | 0.29 | -0.32 | -1.07 | 0.75 |
| 132052 | BRD-K41599323 | HELA | 0.08 uM | 24 h | 0.25 | 1.05 | 0.18 | 0.0 | 0.0 | 0.0 |
| 132127 | BRD-K41599323 | PC3 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |