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CMap Candidate Details

Structure:
CMap ID: C03107
Pert ID: BRD-K61250553
Compound Name: loperamide
Targets: CACNA1A|CALM1|OPRD1|OPRK1|OPRM1|POMC
MoA: opioid receptor agonist
SMILES: CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3848 BRD-K61250553 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9463 BRD-K61250553 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10553 BRD-K61250553 HCT116 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.61
10814 BRD-K61250553 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11529 BRD-K61250553 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.29 1.01 0.46
11798 BRD-K61250553 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12091 BRD-K61250553 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12350 BRD-K61250553 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12828 BRD-K61250553 SW480 10 uM 6 h -0.26 -1.09 0.32 -0.25 -0.85 0.19
44997 BRD-K61250553 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46426 BRD-K61250553 PHH 10 uM 24 h -0.22 -0.93 0.07 -0.22 -0.74 0.05
46752 BRD-K61250553 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50387 BRD-K61250553 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90947 BRD-K61250553 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
98916 BRD-K61250553 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99166 BRD-K61250553 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99288 BRD-K61250553 U2OS 10 uM 6 h 0.2 0.82 0.0 0.33 1.18 0.97
123817 BRD-K61250553 A375 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
123858 BRD-K61250553 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123878 BRD-K61250553 HA1E 10 uM 24 h 0.27 1.12 0.26 0.3 1.05 0.57
123927 BRD-K61250553 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123954 BRD-K61250553 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123975 BRD-K61250553 HT29 10 uM 24 h -0.19 -0.78 0.0 0.27 0.94 0.3
124029 BRD-K61250553 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.38 1.36 1.72
124080 BRD-K61250553 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124107 BRD-K61250553 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124144 BRD-K61250553 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124158 BRD-K61250553 PC3 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
124210 BRD-K61250553 THP1 10 uM 24 h -0.16 -0.67 0.0 -0.27 -0.92 0.31
124263 BRD-K61250553 YAPC 10 uM 24 h 0.26 1.08 0.2 0.39 1.37 1.99
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).