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CMap Candidate Details

Structure:
CMap ID: C03108
Pert ID: BRD-K99451608
Compound Name: lopinavir
Targets:
MoA: HIV protease inhibitor
SMILES: CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)COc1c(C)cccc1C)Cc1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1200 BRD-K99451608 PC3 10 uM 24 h 0.0 0.0 0.0 -0.49 -1.66 15.65
1285 BRD-K99451608 MCF??7.00 10 uM 48 h 0.0 0.0 0.0 0.33 1.15 0.89
1383 BRD-K99451608 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.79
33646 BRD-K99451608 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34223 BRD-K99451608 ASC 10 uM 24 h -0.27 -1.11 0.37 0.29 1.04 0.53
34725 BRD-K99451608 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.49
35003 BRD-K99451608 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.86
35647 BRD-K99451608 NEU 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
35878 BRD-K99451608 NPC 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
36394 BRD-K99451608 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36694 BRD-K99451608 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37020 BRD-K99451608 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
127804 BRD-K99451608 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127889 BRD-K99451608 HEK293 0.04 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.71
127909 BRD-K99451608 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127963 BRD-K99451608 HUVEC 0.37 uM 24 h -0.17 -0.73 0.0 0.31 1.08 0.66
128013 BRD-K99451608 MCF10A 3.33 uM 24 h 0.35 1.46 1.12 0.0 0.0 0.0
128093 BRD-K99451608 YAPC 0.04 uM 24 h -0.23 -0.95 0.09 0.24 0.83 0.12
135535 BRD-K99451608 HA1E 0.01 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
135589 BRD-K99451608 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135681 BRD-K99451608 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).