Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C03118
Pert ID: BRD-K76205745
Compound Name: losartan
Targets: AGTR1
MoA: angiotensin receptor antagonist
SMILES: CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4961 BRD-K76205745 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8982 BRD-K76205745 A375 150 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9504 BRD-K76205745 AGS 150 uM 6 h -0.21 -0.88 0.03 0.0 0.0 0.0
9808 BRD-K76205745 H1299 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10358 BRD-K76205745 HCC515 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10591 BRD-K76205745 HCT116 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10847 BRD-K76205745 HEPG2 150 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.47
11013 BRD-K76205745 HT29 150 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11572 BRD-K76205745 NCIH2073 150 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.12
11835 BRD-K76205745 NCIH508 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12127 BRD-K76205745 NCIH596 150 uM 6 h -0.21 -0.88 0.03 0.0 0.0 0.0
12378 BRD-K76205745 NOMO1 150 uM 6 h 0.21 0.87 0.01 0.0 0.0 0.0
12865 BRD-K76205745 SW480 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13356 BRD-K76205745 U937 150 uM 6 h -0.23 -0.96 0.1 0.2 0.71 0.02
37410 BRD-K76205745 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37735 BRD-K76205745 ASC 10 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
38776 BRD-K76205745 PHH 10 uM 24 h 0.23 0.94 0.06 -0.29 -0.96 0.43
39002 BRD-K76205745 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91480 BRD-K76205745 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
95452 BRD-K76205745 U2OS 0.12 uM 6 h -0.19 -0.81 0.0 0.0 0.0 0.0
127045 BRD-K76205745 HA1E 0.125 uM 24 h 0.21 0.86 0.01 -0.28 -0.94 0.38
127068 BRD-K76205745 HEK293 10 uM 24 h 0.31 1.29 0.68 0.0 0.0 0.0
127102 BRD-K76205745 HELA 0.04 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.78
127184 BRD-K76205745 MCF10A 0.37 uM 24 h 0.26 1.07 0.19 0.0 0.0 0.0
127212 BRD-K76205745 MCF??7.00 0.04 uM 24 h 0.25 1.03 0.13 -0.2 -0.67 0.02
127241 BRD-K76205745 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.46
127316 BRD-K76205745 YAPC 10 uM 24 h 0.29 1.19 0.41 -0.23 -0.76 0.07
135173 BRD-K76205745 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135268 BRD-K76205745 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135307 BRD-K76205745 THP1 0.25 uM 24 h 0.31 1.28 0.62 -0.27 -0.91 0.31
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).