CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03122
Pert ID:	BRD-K39915878
Compound Name:	loxapine
Targets:	ADRA1A\|ADRA1B\|ADRA2A\|ADRA2B\|ADRA2C\|ADRB1\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|HRH1\|HRH2\|HRH4\|HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR2A\|HTR2C\|HTR3A\|HTR5A\|HTR6\|HTR7\|SLC6A2\|SLC6A3\|SLC6A4
MoA:	dopamine receptor antagonist; serotonin receptor antagonist
SMILES:	CN1CCN(CC1)C1=Nc2ccccc2Oc2ccc(Cl)cc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5326	BRD-K39915878	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5773	BRD-K39915878	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
5911	BRD-K39915878	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
6094	BRD-K39915878	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
6546	BRD-K39915878	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
39136	BRD-K39915878	A375	10 uM	6 h	0.0	0.0	0.0	0.28	0.99	0.4
39326	BRD-K39915878	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39697	BRD-K39915878	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40277	BRD-K39915878	HT29	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.97	0.46
40814	BRD-K39915878	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41118	BRD-K39915878	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41453	BRD-K39915878	SKB	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.4
51465	BRD-K39915878	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99927	BRD-K39915878	U2OS	10 uM	6 h	-0.29	-1.21	0.59	0.0	0.0	0.0

Summary