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CMap Candidate Details

Structure:
CMap ID: C03141
Pert ID: BRD-A92826379
Compound Name: lupanine
Targets: INS
MoA: sodium channel blocker
SMILES: O=C1CCCC2C3CC(CN12)[C@@H]1CCCCN1C3
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5419 BRD-A92826379 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5561 BRD-A92826379 HCC515 10 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
5866 BRD-A92826379 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6336 BRD-A92826379 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37566 BRD-A92826379 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38672 BRD-A92826379 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38897 BRD-A92826379 SKB 10 uM 24 h -0.2 -0.85 0.01 0.32 1.14 0.85
100395 BRD-A92826379 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
128372 BRD-A92826379 A549 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128421 BRD-A92826379 HEK293 1.11 uM 24 h -0.3 -1.24 0.66 0.0 0.0 0.0
128472 BRD-A92826379 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128494 BRD-A92826379 HT29 10 uM 24 h -0.24 -1.0 0.15 -0.22 -0.75 0.06
128531 BRD-A92826379 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
128624 BRD-A92826379 MDAMB231 1.11 uM 24 h 0.25 1.05 0.17 0.3 1.05 0.57
128673 BRD-A92826379 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128704 BRD-A92826379 THP1 0.125 uM 24 h 0.29 1.21 0.46 -0.28 -0.95 0.4
128754 BRD-A92826379 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136165 BRD-A92826379 A375 0.08 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
136304 BRD-A92826379 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
136332 BRD-A92826379 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).