CMap Candidate Details
Structure:
| CMap ID: | C03147 |
| Pert ID: | BRD-K32101625 |
| Compound Name: | LX1031 |
| Targets: | TPH1 |
| MoA: | tryptophan hydroxylase inhibitor |
| SMILES: | COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)C(F)(F)F |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 120516 | BRD-K32101625 | A375 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120551 | BRD-K32101625 | A549 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.41 | 1.45 | 2.22 |
| 120652 | BRD-K32101625 | HT29 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120702 | BRD-K32101625 | JURKAT | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120774 | BRD-K32101625 | PC3 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120808 | BRD-K32101625 | YAPC | 0.04 uM | 24 h | -0.21 | -0.86 | 0.01 | 0.0 | 0.0 | 0.0 |
| 129003 | BRD-K32101625 | HA1E | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129032 | BRD-K32101625 | HELA | 0.01 uM | 3 h | 0.0 | 0.0 | 0.0 | -0.23 | -0.78 | 0.09 |
| 129051 | BRD-K32101625 | MCF??7.00 | 0.03 uM | 24 h | -0.21 | -0.86 | 0.01 | -0.24 | -0.8 | 0.12 |