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CMap Candidate Details

Structure:
CMap ID: C03158
Pert ID: BRD-K34313798
Compound Name: LY215490
Targets: GRIA1|GRIA2|GRIA3|GRIA4|GRIK1
MoA: glutamate receptor antagonist
SMILES: OC(=O)[C@@H]1C[C@H]2C[C@@H](CCc3nn[nH]n3)CC[C@H]2CN1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122082 BRD-K34313798 HUVEC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122127 BRD-K34313798 MCF??7.00 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
122155 BRD-K34313798 MDAMB231 10 uM 24 h -0.24 -0.98 0.12 0.0 0.0 0.0
122229 BRD-K34313798 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.26
130192 BRD-K34313798 A375 0.01 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.73
130213 BRD-K34313798 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130247 BRD-K34313798 HA1E 0.08 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
130273 BRD-K34313798 HEK293 0.01 uM 24 h -0.37 -1.53 1.43 0.0 0.0 0.0
130309 BRD-K34313798 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130331 BRD-K34313798 HT29 2.22 uM 24 h -0.16 -0.68 0.0 0.0 0.0 0.0
130382 BRD-K34313798 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130422 BRD-K34313798 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130487 BRD-K34313798 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
130512 BRD-K34313798 THP1 0.08 uM 24 h -0.22 -0.91 0.05 0.25 0.88 0.18
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).