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CMap Candidate Details

Structure:
CMap ID: C03161
Pert ID: BRD-K59227464
Compound Name: LY2228820
Targets: MAPK14
MoA: p38 MAPK inhibitor
SMILES: CC(C)(C)Cn1c(N)nc2ccc(nc12)-c1[nH]c(nc1-c1ccc(F)cc1)C(C)(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
98100 BRD-K59227464 P1A82 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123537 BRD-K59227464 HA1E 10 uM 24 h -0.24 -1.01 0.15 -0.29 -0.98 0.47
123571 BRD-K59227464 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123617 BRD-K59227464 HELA 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
123647 BRD-K59227464 HT29 10 uM 24 h 0.28 1.17 0.38 0.25 0.9 0.21
123688 BRD-K59227464 MCF10A 10 uM 24 h 0.27 1.13 0.28 -0.3 -1.02 0.61
123724 BRD-K59227464 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123764 BRD-K59227464 YAPC 10 uM 24 h 0.0 0.0 0.0 0.38 1.33 1.72
131979 BRD-K59227464 A375 0.03 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
132111 BRD-K59227464 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).