CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03170
Pert ID:	BRD-K14109347
Compound Name:	LY2603618
Targets:	CHEK1
MoA:	CHK inhibitor
SMILES:	Cc1cnc(NC(=O)Nc2cc(Br)c(C)cc2OC[C@@H]2CNCCO2)cn1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
93634	BRD-K14109347	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93688	BRD-K14109347	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93742	BRD-K14109347	CD34	10 uM	24 h	0.38	1.59	1.52	0.0	0.0	0.0
93776	BRD-K14109347	HA1E	3.33 uM	24 h	0.27	1.14	0.32	0.0	0.0	0.0
93816	BRD-K14109347	HCC515	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93867	BRD-K14109347	HEK293	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93907	BRD-K14109347	HELA	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93949	BRD-K14109347	HEPG2	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93975	BRD-K14109347	HUVEC	1.11 uM	24 h	0.2	0.81	0.0	0.0	0.0	0.0
94050	BRD-K14109347	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94079	BRD-K14109347	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94130	BRD-K14109347	NEU	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94147	BRD-K14109347	NPC	3.33 uM	24 h	0.22	0.94	0.05	0.0	0.0	0.0
94210	BRD-K14109347	PC3	10 uM	24 h	0.0	0.0	0.0	0.34	1.19	1.03
94265	BRD-K14109347	SHSY5Y	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94316	BRD-K14109347	SKL	10 uM	24 h	0.0	0.0	0.0	0.36	1.29	1.45
94360	BRD-K14109347	THP1	1.11 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.93
94398	BRD-K14109347	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary