CMap Candidate Details
Structure:
| CMap ID: | C03174 |
| Pert ID: | BRD-K25630527 |
| Compound Name: | LY2784544 |
| Targets: | JAK2|JAK3 |
| MoA: | JAK inhibitor |
| SMILES: | Cc1cc(Nc2cc(CN3CCOCC3)c3nc(C)c(Cc4ccc(Cl)cc4F)n3n2)[nH]n1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 95673 | BRD-K25630527 | U2OS | 1.11 uM | 48 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120893 | BRD-K25630527 | A549 | 3.33 uM | 24 h | 0.24 | 0.98 | 0.09 | 0.42 | 1.49 | 2.26 |
| 120920 | BRD-K25630527 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120970 | BRD-K25630527 | HEK293 | 10 uM | 24 h | -0.24 | -1.01 | 0.17 | 0.0 | 0.0 | 0.0 |
| 121057 | BRD-K25630527 | MCF??7.00 | 10 uM | 24 h | 0.23 | 0.95 | 0.07 | -0.27 | -0.91 | 0.3 |
| 121127 | BRD-K25630527 | YAPC | 10 uM | 24 h | -0.2 | -0.85 | 0.01 | -0.35 | -1.17 | 1.14 |
| 129102 | BRD-K25630527 | A375 | 2.22 uM | 24 h | 0.21 | 0.87 | 0.01 | 0.0 | 0.0 | 0.0 |
| 129171 | BRD-K25630527 | HELA | 2.22 uM | 3 h | 0.24 | 0.99 | 0.1 | 0.0 | 0.0 | 0.0 |
| 129203 | BRD-K25630527 | HT29 | 2.22 uM | 24 h | -0.33 | -1.38 | 1.08 | 0.0 | 0.0 | 0.0 |
| 129229 | BRD-K25630527 | PC3 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.38 | -1.29 | 1.53 |