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CMap Candidate Details

Structure:
CMap ID: C03176
Pert ID: BRD-K94534639
Compound Name: LY2811376
Targets: BACE1
MoA: beta-secretase inhibitor
SMILES: C[C@]1(CCSC(N)=N1)c1cc(c(F)cc1F)-c1cncnc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95661 BRD-K94534639 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
96625 BRD-K94534639 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128165 BRD-K94534639 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128214 BRD-K94534639 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128293 BRD-K94534639 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135774 BRD-K94534639 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135803 BRD-K94534639 HA1E 0.01 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
135888 BRD-K94534639 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135936 BRD-K94534639 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135977 BRD-K94534639 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 -0.33 -1.13 0.97
136024 BRD-K94534639 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136054 BRD-K94534639 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136084 BRD-K94534639 THP1 2.22 uM 24 h 0.33 1.39 1.02 0.21 0.75 0.04
136123 BRD-K94534639 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).