CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03186
Pert ID:	BRD-K22385716
Compound Name:	LY303511
Targets:	BRD2\|BRD3\|BRD4
MoA:	casein kinase inhibitor; mTOR inhibitor; PI3K inhibitor
SMILES:	O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2852	BRD-K22385716	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.38	-1.28	1.45
3162	BRD-K22385716	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3476	BRD-K22385716	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3751	BRD-K22385716	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44341	BRD-K22385716	A375	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.97	0.47
44685	BRD-K22385716	A549	10 uM	6 h	0.0	0.0	0.0	-0.44	-1.49	15.35
44899	BRD-K22385716	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
45202	BRD-K22385716	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
45468	BRD-K22385716	HT29	10 uM	6 h	-0.23	-0.97	0.11	0.0	0.0	0.0
45671	BRD-K22385716	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46017	BRD-K22385716	NPC	10 uM	24 h	0.21	0.88	0.01	-0.39	-1.3	1.61
46335	BRD-K22385716	PHH	10 uM	24 h	0.31	1.31	0.73	-0.23	-0.77	0.08
46652	BRD-K22385716	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
97303	BRD-K22385716	HAP1	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99753	BRD-K22385716	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary