CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00320
Pert ID:	BRD-K45924332
Compound Name:	amrinone
Targets:	PDE3A\|PDE3B\|PDE4B\|TNF
MoA:	phosphodiesterase inhibitor
SMILES:	Nc1cc(c[nH]c1=O)-c1ccncc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125589	BRD-K45924332	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125676	BRD-K45924332	HELA	10 uM	24 h	0.24	0.99	0.1	-0.28	-0.94	0.38
125742	BRD-K45924332	HUVEC	3.33 uM	24 h	-0.22	-0.9	0.04	0.0	0.0	0.0
125782	BRD-K45924332	JURKAT	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125940	BRD-K45924332	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133670	BRD-K45924332	A549	0.25 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.78
133705	BRD-K45924332	HA1E	0.03 uM	24 h	0.26	1.1	0.24	0.0	0.0	0.0
133736	BRD-K45924332	HEK293	0.74 uM	24 h	0.0	0.0	0.0	-0.44	-1.49	15.35
133802	BRD-K45924332	HT29	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133863	BRD-K45924332	MCF10A	0.08 uM	24 h	0.19	0.8	0.0	0.0	0.0	0.0
133887	BRD-K45924332	MCF??7.00	2.22 uM	24 h	0.22	0.91	0.03	0.0	0.0	0.0
133918	BRD-K45924332	MDAMB231	0.03 uM	24 h	0.27	1.14	0.32	0.0	0.0	0.0
133948	BRD-K45924332	PC3	0.74 uM	24 h	0.28	1.16	0.35	0.0	0.0	0.0
133982	BRD-K45924332	THP1	0.25 uM	24 h	-0.26	-1.1	0.33	0.0	0.0	0.0

Summary