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CMap Candidate Details

Structure:
CMap ID: C00322
Pert ID: BRD-K68346641
Compound Name: amsacrine
Targets: KCNH2|TOP2A
MoA: topoisomerase inhibitor
SMILES: COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
53040 BRD-K68346641 HEPG2 100 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
53162 BRD-K68346641 MCF10A 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
126621 BRD-K68346641 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126646 BRD-K68346641 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126686 BRD-K68346641 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126708 BRD-K68346641 HELA 0.125 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
126762 BRD-K68346641 JURKAT 0.37 uM 24 h -0.19 -0.8 0.0 0.0 0.0 0.0
126829 BRD-K68346641 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126872 BRD-K68346641 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.38 1.35 1.72
126933 BRD-K68346641 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126982 BRD-K68346641 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134719 BRD-K68346641 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134817 BRD-K68346641 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134848 BRD-K68346641 HUVEC 0.25 uM 24 h 0.19 0.8 0.0 -0.4 -1.33 1.77
134956 BRD-K68346641 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).