CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03220
Pert ID:	BRD-K21396683
Compound Name:	marimastat
Targets:	MMP1\|MMP10\|MMP11\|MMP12\|MMP13\|MMP14\|MMP15\|MMP16\|MMP17\|MMP19\|MMP2\|MMP20\|MMP21\|MMP23A\|MMP24\|MMP25\|MMP26\|MMP27\|MMP28\|MMP3\|MMP7\|MMP8\|MMP9
MoA:	matrix metalloprotease inhibitor
SMILES:	CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
120944	BRD-K21396683	HEK293	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121013	BRD-K21396683	HT29	0.37 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.41
121036	BRD-K21396683	MCF??7.00	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121102	BRD-K21396683	YAPC	0.125 uM	24 h	0.0	0.0	0.0	-0.33	-1.13	0.97
129094	BRD-K21396683	A375	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129111	BRD-K21396683	A549	2.22 uM	24 h	-0.27	-1.13	0.4	0.0	0.0	0.0
129130	BRD-K21396683	HA1E	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129148	BRD-K21396683	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129218	BRD-K21396683	PC3	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary