CMap Candidate Details
Structure:
| CMap ID: | C03228 |
| Pert ID: | BRD-A68464583 |
| Compound Name: | mazindol |
| Targets: | SLC6A2|SLC6A3|SLC6A4 |
| MoA: | dopamine reuptake inhibitor; selective serotonin reuptake inhibitor (SSRI) |
| SMILES: | OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 126797 | BRD-A68464583 | MCF10A | 3.33 uM | 24 h | -0.26 | -1.06 | 0.26 | -0.28 | -0.95 | 0.4 |
| 126830 | BRD-A68464583 | MCF??7.00 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.33 | -1.1 | 0.88 |
| 126873 | BRD-A68464583 | MDAMB231 | 10 uM | 24 h | 0.22 | 0.9 | 0.03 | 0.0 | 0.0 | 0.0 |
| 126934 | BRD-A68464583 | THP1 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126983 | BRD-A68464583 | YAPC | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134670 | BRD-A68464583 | A375 | 0.08 uM | 24 h | -0.26 | -1.1 | 0.35 | 0.31 | 1.09 | 0.68 |
| 134693 | BRD-A68464583 | A549 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134720 | BRD-A68464583 | HA1E | 0.01 uM | 24 h | -0.22 | -0.92 | 0.06 | 0.26 | 0.94 | 0.28 |
| 134755 | BRD-A68464583 | HEK293 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.34 | -1.14 | 1.01 |
| 134789 | BRD-A68464583 | HELA | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134818 | BRD-A68464583 | HT29 | 0.03 uM | 24 h | -0.25 | -1.02 | 0.19 | -0.35 | -1.19 | 1.15 |
| 134849 | BRD-A68464583 | HUVEC | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.33 | -1.12 | 0.92 |
| 134898 | BRD-A68464583 | JURKAT | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.44 | -1.48 | 15.35 |
| 134957 | BRD-A68464583 | PC3 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |