CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00324
Pert ID:	BRD-K70924353
Compound Name:	amtolmetin-guacil
Targets:	PTGS1\|PTGS2
MoA:	cyclooxygenase inhibitor
SMILES:	COc1ccccc1OC(=O)CNC(=O)Cc1ccc(C(=O)c2ccc(C)cc2)n1C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
126697	BRD-K70924353	HEK293	0.37 uM	24 h	-0.22	-0.93	0.07	-0.18	-0.62	0.0
126722	BRD-K70924353	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126806	BRD-K70924353	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126845	BRD-K70924353	MCF??7.00	10 uM	24 h	0.2	0.84	0.0	0.0	0.0	0.0
126890	BRD-K70924353	MDAMB231	0.125 uM	24 h	-0.22	-0.93	0.07	0.0	0.0	0.0
126957	BRD-K70924353	THP1	1.11 uM	24 h	0.19	0.79	0.0	0.0	0.0	0.0
126998	BRD-K70924353	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.22	0.76	0.05
134682	BRD-K70924353	A375	0.25 uM	24 h	0.0	0.0	0.0	0.27	0.95	0.32
134704	BRD-K70924353	A549	0.03 uM	24 h	0.0	0.0	0.0	0.36	1.28	1.42
134732	BRD-K70924353	HA1E	0.01 uM	24 h	0.0	0.0	0.0	0.24	0.86	0.16
134829	BRD-K70924353	HT29	2.22 uM	24 h	-0.25	-1.03	0.19	0.0	0.0	0.0
134871	BRD-K70924353	HUVEC	0.08 uM	24 h	0.0	0.0	0.0	0.24	0.86	0.15
134900	BRD-K70924353	JURKAT	2.22 uM	24 h	-0.19	-0.81	0.0	0.24	0.84	0.13
134968	BRD-K70924353	PC3	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary