CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00325
Pert ID:	BRD-K66538826
Compound Name:	amuvatinib
Targets:	KIT\|MET
MoA:	FLT3 inhibitor; KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; RAD51 inhibitor; RET tyrosine kinase inhibitor
SMILES:	S=C(NCc1ccc2OCOc2c1)N1CCN(CC1)c1ncnc2c3ccccc3oc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91822	BRD-K66538826	HS578T	0.08 uM	6 h	0.28	1.15	0.34	-0.26	-0.88	0.24
91970	BRD-K66538826	SKBR3	0.08 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
92913	BRD-K66538826	ASC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92970	BRD-K66538826	CD34	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93028	BRD-K66538826	HA1E	10 uM	24 h	-0.3	-1.26	0.72	0.0	0.0	0.0
93061	BRD-K66538826	HEK293	10 uM	24 h	0.0	0.0	0.0	-0.22	-0.75	0.06
93150	BRD-K66538826	HEPG2	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.86
93197	BRD-K66538826	HUVEC	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93254	BRD-K66538826	JURKAT	1.11 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
93380	BRD-K66538826	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93502	BRD-K66538826	SKL	0.04 uM	24 h	0.0	0.0	0.0	0.27	0.97	0.35
93526	BRD-K66538826	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95431	BRD-K66538826	U2OS	10 uM	48 h	0.0	0.0	0.0	-0.33	-1.1	0.88
124980	BRD-K66538826	A549	10 uM	24 h	0.0	0.0	0.0	-0.3	-0.99	0.51
125060	BRD-K66538826	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125082	BRD-K66538826	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125221	BRD-K66538826	YAPC	10 uM	24 h	-0.28	-1.17	0.48	0.0	0.0	0.0
132986	BRD-K66538826	A375	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133098	BRD-K66538826	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133240	BRD-K66538826	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133269	BRD-K66538826	MDAMB231	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133300	BRD-K66538826	PC3	2.22 uM	24 h	-0.25	-1.04	0.21	-0.35	-1.19	1.15

Summary