CMap Candidate Details
Structure:
CMap ID: | C03276 |
Pert ID: | BRD-K82244583 |
Compound Name: | MEK162 |
Targets: | MAP2K1|MAP2K2 |
MoA: | MEK inhibitor |
SMILES: | Cn1cnc2c(F)c(Nc3ccc(Br)cc3F)c(cc12)C(=O)NOCCO |
InchiKey: | |
Compound Aliases: |
Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
---|---|---|---|---|---|---|---|---|---|---|
126029 | BRD-K82244583 | HELA | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.25 | 0.87 | 0.17 |
126076 | BRD-K82244583 | HUVEC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.3 | 1.58 |
126121 | BRD-K82244583 | JURKAT | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
126174 | BRD-K82244583 | MCF10A | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
126259 | BRD-K82244583 | PC3 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.98 | 0.48 |
126293 | BRD-K82244583 | THP1 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
126338 | BRD-K82244583 | YAPC | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.36 | 1.28 | 1.37 |
134003 | BRD-K82244583 | A375 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.25 | 0.87 | 0.17 |
134034 | BRD-K82244583 | A549 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
134063 | BRD-K82244583 | HA1E | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.35 | 1.25 | 1.29 |
134095 | BRD-K82244583 | HEK293 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.3 | 1.07 | 0.63 |
134179 | BRD-K82244583 | HT29 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
134225 | BRD-K82244583 | MCF??7.00 | 0.74 uM | 24 h | -0.26 | -1.07 | 0.27 | 0.33 | 1.17 | 0.93 |
134253 | BRD-K82244583 | MDAMB231 | 2.22 uM | 24 h | 0.18 | 0.76 | 0.0 | 0.0 | 0.0 | 0.0 |