CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03282
Pert ID:	BRD-K92984783
Compound Name:	melperone
Targets:	DRD2\|HTR2A
MoA:	dopamine receptor antagonist; serotonin receptor antagonist
SMILES:	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2144	BRD-K92984783	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
2447	BRD-K92984783	PC3	10 uM	6 h	0.0	0.0	0.0	-0.25	-0.84	0.17
25545	BRD-K92984783	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
39834	BRD-K92984783	ASC	10 uM	24 h	0.0	0.0	0.0	-0.19	-0.63	0.01
40124	BRD-K92984783	HEPG2	10 uM	6 h	-0.3	-1.25	0.7	0.0	0.0	0.0
41257	BRD-K92984783	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41595	BRD-K92984783	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128371	BRD-K92984783	A549	0.04 uM	24 h	0.24	0.98	0.09	-0.36	-1.22	1.24
128420	BRD-K92984783	HEK293	1.11 uM	24 h	0.0	0.0	0.0	-0.3	-1.01	0.58
128471	BRD-K92984783	HELA	1.11 uM	24 h	-0.31	-1.28	0.77	0.23	0.82	0.1
128493	BRD-K92984783	HT29	0.37 uM	24 h	0.0	0.0	0.0	0.32	1.13	0.84
128530	BRD-K92984783	JURKAT	10 uM	24 h	-0.22	-0.93	0.07	-0.27	-0.92	0.33
128623	BRD-K92984783	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128703	BRD-K92984783	THP1	0.125 uM	24 h	0.0	0.0	0.0	-0.28	-0.94	0.37
136164	BRD-K92984783	A375	0.08 uM	24 h	0.0	0.0	0.0	-0.22	-0.74	0.06
136210	BRD-K92984783	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136303	BRD-K92984783	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136331	BRD-K92984783	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.31	1.09	0.67
136380	BRD-K92984783	YAPC	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary