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CMap Candidate Details

Structure:
CMap ID: C03287
Pert ID: BRD-K78126613
Compound Name: menadione
Targets: AOX1|BGLAP|F10|F2|F7|F9|GGCX|NQO1|NQO2|PROC|PROS1|PROZ|VKORC1|VKORC1L1
MoA: mitochondrial DNA polymerase inhibitor; phosphatase inhibitor
SMILES: CC1=CC(=O)c2ccccc2C1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9813 BRD-K78126613 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10127 BRD-K78126613 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.16
10595 BRD-K78126613 HCT116 10 uM 6 h 0.0 0.0 0.0 0.23 0.8 0.08
11298 BRD-K78126613 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11574 BRD-K78126613 NCIH2073 10 uM 6 h -0.31 -1.31 0.82 0.0 0.0 0.0
12132 BRD-K78126613 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12381 BRD-K78126613 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12628 BRD-K78126613 PC3 10 uM 6 h 0.19 0.78 0.0 -0.23 -0.78 0.1
12869 BRD-K78126613 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13361 BRD-K78126613 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13681 BRD-K78126613 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44448 BRD-K78126613 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45034 BRD-K78126613 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45323 BRD-K78126613 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.48 -1.6 15.65
45581 BRD-K78126613 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46146 BRD-K78126613 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46787 BRD-K78126613 SKB 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
90574 BRD-K78126613 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97561 BRD-K78126613 NKDBA 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127443 BRD-K78126613 HA1E 3.33 uM 24 h -0.27 -1.11 0.37 -0.38 -1.28 1.45
127533 BRD-K78126613 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127564 BRD-K78126613 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127658 BRD-K78126613 THP1 3.33 uM 24 h 0.23 0.96 0.07 -0.43 -1.45 15.35
127706 BRD-K78126613 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135379 BRD-K78126613 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).