CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03299
Pert ID:	BRD-A03216249
Compound Name:	mepivacaine
Targets:	SCN10A
MoA:	potassium channel blocker; sodium channel blocker
SMILES:	CN1CCCCC1C(=O)Nc1c(C)cccc1C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
22625	BRD-A03216249	HCC515	10 uM	6 h	-0.18	-0.73	0.0	0.0	0.0	0.0
22906	BRD-A03216249	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.26	-0.88	0.24
24071	BRD-A03216249	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122869	BRD-A03216249	HA1E	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122921	BRD-A03216249	HEK293	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122994	BRD-A03216249	HT29	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123046	BRD-A03216249	JURKAT	1.11 uM	24 h	-0.29	-1.21	0.6	0.28	0.98	0.37
123083	BRD-A03216249	MCF??7.00	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123136	BRD-A03216249	MDAMB231	10 uM	24 h	0.32	1.32	0.79	0.41	1.43	2.21
123206	BRD-A03216249	THP1	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131220	BRD-A03216249	A375	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131262	BRD-A03216249	A549	0.25 uM	24 h	0.0	0.0	0.0	0.3	1.05	0.57
131318	BRD-A03216249	HELA	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131383	BRD-A03216249	HUVEC	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131418	BRD-A03216249	MCF10A	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131475	BRD-A03216249	PC3	0.25 uM	24 h	0.18	0.77	0.0	0.0	0.0	0.0
131516	BRD-A03216249	YAPC	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary