CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03308
Pert ID:	BRD-K91601245
Compound Name:	mercaptopurine
Targets:	HPRT1\|IMPDH1\|IMPDH2\|PPAT
MoA:	immunosuppressant; protein synthesis inhibitor; purine antagonist
SMILES:	S=c1[nH]cnc2nc[nH]c12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
50699	BRD-K91601245	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.41	-1.38	2.02
51192	BRD-K91601245	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
127745	BRD-K91601245	A375	10 uM	24 h	0.2	0.84	0.0	0.0	0.0	0.0
127790	BRD-K91601245	A549	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127825	BRD-K91601245	HA1E	10 uM	24 h	-0.31	-1.28	0.74	-0.29	-0.99	0.5
127870	BRD-K91601245	HEK293	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127901	BRD-K91601245	HT29	10 uM	24 h	0.0	0.0	0.0	-0.36	-1.22	1.24
127944	BRD-K91601245	HUVEC	1.11 uM	24 h	0.0	0.0	0.0	0.25	0.87	0.17
127997	BRD-K91601245	MCF10A	1.11 uM	24 h	0.21	0.89	0.02	0.36	1.28	1.36
135571	BRD-K91601245	HELA	2.22 uM	24 h	0.23	0.97	0.08	-0.3	-1.0	0.52
135662	BRD-K91601245	JURKAT	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135720	BRD-K91601245	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.34	1.19	1.01
135746	BRD-K91601245	YAPC	0.08 uM	24 h	0.3	1.23	0.5	0.0	0.0	0.0

Summary