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CMap Candidate Details

Structure:
CMap ID: C00336
Pert ID: BRD-K62200014
Compound Name: anagrelide
Targets: PDE3A
MoA: phosphodiesterase inhibitor
SMILES: Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1373 BRD-K62200014 U2OS 1.11 uM 48 h -0.26 -1.08 0.3 0.0 0.0 0.0
5659 BRD-K62200014 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5937 BRD-K62200014 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6404 BRD-K62200014 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37709 BRD-K62200014 ASC 10 uM 24 h -0.3 -1.25 0.71 0.0 0.0 0.0
38214 BRD-K62200014 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38530 BRD-K62200014 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90970 BRD-K62200014 HUH7 12.5 uM 72 h 0.0 0.0 0.0 -0.35 -1.18 1.14
124955 BRD-K62200014 A549 10 uM 24 h -0.28 -1.18 0.5 0.0 0.0 0.0
125047 BRD-K62200014 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125068 BRD-K62200014 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125146 BRD-K62200014 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.21
132973 BRD-K62200014 A375 2.22 uM 24 h 0.18 0.75 0.0 0.25 0.9 0.21
133006 BRD-K62200014 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133032 BRD-K62200014 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133083 BRD-K62200014 HELA 0.03 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
133139 BRD-K62200014 JURKAT 0.08 uM 24 h -0.23 -0.96 0.1 -0.3 -1.02 0.6
133253 BRD-K62200014 MDAMB231 0.01 uM 24 h -0.27 -1.14 0.43 0.0 0.0 0.0
133281 BRD-K62200014 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133310 BRD-K62200014 YAPC 0.03 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).