CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03362
Pert ID:	BRD-K48578705
Compound Name:	methyldopa
Targets:	ADRA2A\|ADRA2B\|ADRA2C\|DDC
MoA:	adrenergic receptor agonist
SMILES:	C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91220	BRD-K48578705	HUH7	15 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
125595	BRD-K48578705	A375	0.125 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.7
125658	BRD-K48578705	HEK293	0.125 uM	24 h	-0.26	-1.08	0.29	0.0	0.0	0.0
125679	BRD-K48578705	HELA	0.04 uM	24 h	0.26	1.07	0.19	0.42	1.49	2.25
125748	BRD-K48578705	HUVEC	1.11 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.64
125784	BRD-K48578705	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125946	BRD-K48578705	YAPC	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133673	BRD-K48578705	A549	0.01 uM	24 h	-0.31	-1.27	0.74	0.0	0.0	0.0
133710	BRD-K48578705	HA1E	0.01 uM	24 h	0.0	0.0	0.0	0.28	1.01	0.44
133806	BRD-K48578705	HT29	0.01 uM	24 h	0.0	0.0	0.0	0.25	0.88	0.19
133865	BRD-K48578705	MCF10A	0.01 uM	24 h	0.0	0.0	0.0	0.24	0.85	0.14
133891	BRD-K48578705	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	-0.21	-0.69	0.03
133923	BRD-K48578705	MDAMB231	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133952	BRD-K48578705	PC3	2.22 uM	24 h	-0.21	-0.86	0.01	-0.21	-0.71	0.03
133986	BRD-K48578705	THP1	0.01 uM	24 h	-0.24	-1.01	0.17	0.0	0.0	0.0

Summary