CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00337
Pert ID:	BRD-K01174345
Compound Name:	anamorelin
Targets:	GHSR
MoA:	growth hormone secretagogue receptor agonist
SMILES:	CN(C)N(C)C(=O)[C@@]1(Cc2ccccc2)CCCN(C1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
122887	BRD-K01174345	HEK293	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122967	BRD-K01174345	HT29	10 uM	24 h	0.17	0.71	0.0	0.0	0.0	0.0
123012	BRD-K01174345	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123101	BRD-K01174345	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	-0.24	-0.81	0.14
123173	BRD-K01174345	THP1	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131205	BRD-K01174345	A375	0.25 uM	24 h	-0.21	-0.86	0.02	-0.44	-1.5	15.35
131238	BRD-K01174345	A549	0.01 uM	24 h	0.0	0.0	0.0	0.26	0.91	0.23
131275	BRD-K01174345	HA1E	0.25 uM	24 h	-0.31	-1.28	0.76	0.0	0.0	0.0
131301	BRD-K01174345	HELA	0.25 uM	24 h	0.28	1.17	0.37	-0.27	-0.9	0.29
131349	BRD-K01174345	HUVEC	0.08 uM	24 h	-0.21	-0.87	0.02	0.0	0.0	0.0
131394	BRD-K01174345	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131431	BRD-K01174345	MCF??7.00	0.74 uM	24 h	0.0	0.0	0.0	-0.45	-1.52	15.35
131459	BRD-K01174345	PC3	0.01 uM	24 h	0.0	0.0	0.0	-0.22	-0.75	0.06
131489	BRD-K01174345	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.35	1.23	1.19

Summary