CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03380
Pert ID:	BRD-K75641298
Compound Name:	metoclopramide
Targets:	CHRM1\|DRD2\|HTR3A\|HTR3B\|HTR4
MoA:	dopamine receptor antagonist; serotonin receptor antagonist
SMILES:	CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2920	BRD-K75641298	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.79
3257	BRD-K75641298	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3857	BRD-K75641298	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44617	BRD-K75641298	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
45024	BRD-K75641298	ASC	10 uM	24 h	0.0	0.0	0.0	0.26	0.91	0.24
45316	BRD-K75641298	HEPG2	10 uM	6 h	0.3	1.25	0.54	-0.22	-0.73	0.05
46137	BRD-K75641298	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46453	BRD-K75641298	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46778	BRD-K75641298	SKB	10 uM	24 h	-0.26	-1.1	0.34	0.0	0.0	0.0
91020	BRD-K75641298	HUH7	12 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
96321	BRD-K75641298	A375	3.33 uM	24 h	0.0	0.0	0.0	0.33	1.17	0.94
99467	BRD-K75641298	U2OS	10 uM	6 h	0.25	1.04	0.15	0.0	0.0	0.0
127470	BRD-K75641298	HELA	0.04 uM	24 h	0.2	0.82	0.0	0.32	1.14	0.87
127524	BRD-K75641298	JURKAT	0.37 uM	24 h	0.24	0.99	0.1	0.0	0.0	0.0
127614	BRD-K75641298	PC3	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.96	0.44
127694	BRD-K75641298	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135410	BRD-K75641298	HT29	0.25 uM	24 h	0.0	0.0	0.0	-0.3	-1.01	0.57
135442	BRD-K75641298	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	0.41	1.44	2.21
135475	BRD-K75641298	MCF??7.00	2.22 uM	24 h	-0.19	-0.77	0.0	0.35	1.23	1.22
135502	BRD-K75641298	THP1	0.74 uM	24 h	0.0	0.0	0.0	-0.35	-1.19	1.16

Summary