CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03382
Pert ID:	BRD-A61793559
Compound Name:	metolazone
Targets:	SLC12A3
MoA:	carbonic anhydrase inhibitor
SMILES:	CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5535	BRD-A61793559	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
6476	BRD-A61793559	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
44778	BRD-A61793559	ASC	10 uM	24 h	0.0	0.0	0.0	0.37	1.3	1.59
45097	BRD-A61793559	HEPG2	10 uM	6 h	-0.23	-0.96	0.1	0.21	0.75	0.04
45617	BRD-A61793559	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.37	1.31	1.59
45897	BRD-A61793559	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46214	BRD-A61793559	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46529	BRD-A61793559	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
100250	BRD-A61793559	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
124584	BRD-A61793559	A375	0.125 uM	24 h	-0.3	-1.25	0.69	0.0	0.0	0.0
124623	BRD-A61793559	HA1E	0.37 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.79
124669	BRD-A61793559	HELA	0.37 uM	24 h	0.22	0.93	0.05	-0.26	-0.87	0.23
124703	BRD-A61793559	HT29	0.37 uM	24 h	0.24	0.99	0.1	-0.26	-0.88	0.24
124732	BRD-A61793559	JURKAT	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124809	BRD-A61793559	MDAMB231	1.11 uM	24 h	0.35	1.45	1.12	0.0	0.0	0.0
124852	BRD-A61793559	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132701	BRD-A61793559	A549	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132766	BRD-A61793559	HEK293	0.25 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.12
132880	BRD-A61793559	MCF10A	2.22 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.44
132934	BRD-A61793559	THP1	0.08 uM	24 h	0.3	1.27	0.58	0.0	0.0	0.0
132965	BRD-A61793559	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary