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CMap Candidate Details

Structure:
CMap ID: C03399
Pert ID: BRD-K56277358
Compound Name: MGCD-265
Targets: AXL|MET
MoA: VEGFR inhibitor
SMILES: Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91815 BRD-K56277358 HS578T 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91915 BRD-K56277358 MDAMB231 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91965 BRD-K56277358 SKBR3 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
94425 BRD-K56277358 A375 10 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
94460 BRD-K56277358 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94494 BRD-K56277358 ASC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94568 BRD-K56277358 CD34 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94612 BRD-K56277358 HCC515 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94656 BRD-K56277358 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94705 BRD-K56277358 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94763 BRD-K56277358 HME1 10 uM 24 h 0.19 0.77 0.0 -0.29 -0.98 0.48
94803 BRD-K56277358 HT29 0.37 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
94855 BRD-K56277358 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94905 BRD-K56277358 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94951 BRD-K56277358 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94986 BRD-K56277358 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95033 BRD-K56277358 NEU 0.04 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
95060 BRD-K56277358 NPC 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
95130 BRD-K56277358 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95181 BRD-K56277358 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95220 BRD-K56277358 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95290 BRD-K56277358 THP1 3.33 uM 24 h 0.2 0.85 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).