CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03401
Pert ID:	BRD-A19661776
Compound Name:	mianserin
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|DRD1\|DRD2\|DRD3\|DRD5\|HRH1\|HRH2\|HRH4\|HTR1A\|HTR1F\|HTR2A\|HTR2B\|HTR2C\|HTR6\|HTR7\|OPRK1\|SLC6A2\|SLC6A3\|SLC6A4
MoA:	serotonin receptor antagonist
SMILES:	CN1CCN2C(C1)c1ccccc1Cc1ccccc21
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3311	BRD-A19661776	HCC515	10 uM	6 h	0.0	0.0	0.0	0.21	0.73	0.03
3669	BRD-A19661776	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.79	0.11
39553	BRD-A19661776	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40561	BRD-A19661776	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	-0.19	-0.66	0.01
40685	BRD-A19661776	NEU	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.3
40979	BRD-A19661776	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41302	BRD-A19661776	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
90902	BRD-A19661776	HUH7	12.5 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
120855	BRD-A19661776	A375	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120900	BRD-A19661776	HA1E	1.11 uM	24 h	-0.25	-1.03	0.19	0.0	0.0	0.0
120933	BRD-A19661776	HEK293	0.04 uM	24 h	0.0	0.0	0.0	-0.27	-0.92	0.32
121066	BRD-A19661776	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121091	BRD-A19661776	YAPC	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129107	BRD-A19661776	A549	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129159	BRD-A19661776	HELA	0.25 uM	3 h	0.0	0.0	0.0	0.34	1.2	1.1
129181	BRD-A19661776	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary