CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03403
Pert ID:	BRD-K09549677
Compound Name:	mibefradil
Targets:	ANO1\|CACNA1C\|CACNA1D\|CACNA1F\|CACNA1G\|CACNA1H\|CACNA1I\|CACNA1S\|CACNB1\|CACNB2\|CACNB3\|CACNB4\|CATSPER1\|CATSPER2\|CATSPER3\|CATSPER4
MoA:	T-type calcium channel blocker
SMILES:	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1734	BRD-K09549677	HA1E	10 uM	6 h	0.0	0.0	0.0	0.4	1.43	2.2
1879	BRD-K09549677	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42285	BRD-K09549677	ASC	10 uM	24 h	0.0	0.0	0.0	0.31	1.1	0.7
42619	BRD-K09549677	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.3	1.05	0.57
43478	BRD-K09549677	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
43783	BRD-K09549677	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44063	BRD-K09549677	SKB	10 uM	24 h	0.0	0.0	0.0	0.36	1.27	1.34
88533	BRD-K09549677	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.21	-0.72	0.04
100051	BRD-K09549677	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
121154	BRD-K09549677	A375	10 uM	24 h	0.3	1.24	0.53	0.0	0.0	0.0
121191	BRD-K09549677	A549	10 uM	24 h	0.0	0.0	0.0	0.43	1.51	2.27
121269	BRD-K09549677	HELA	10 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
121280	BRD-K09549677	HT29	10 uM	24 h	0.2	0.85	0.01	-0.18	-0.6	0.0
121319	BRD-K09549677	PC3	10 uM	24 h	0.23	0.98	0.09	0.0	0.0	0.0
121349	BRD-K09549677	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129337	BRD-K09549677	MCF??7.00	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary