CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03409
Pert ID:	BRD-A79981887
Compound Name:	midodrine
Targets:	ADRA1A\|ADRA1B\|ADRA1D
MoA:	adrenergic receptor agonist
SMILES:	COc1ccc(OC)c(c1)C(O)CNC(=O)CN
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5414	BRD-A79981887	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
5551	BRD-A79981887	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
6492	BRD-A79981887	VCAP	10 uM	6 h	0.21	0.87	0.01	-0.31	-1.03	0.62
37555	BRD-A79981887	ASC	10 uM	24 h	0.0	0.0	0.0	-0.39	-1.31	1.69
37856	BRD-A79981887	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38397	BRD-A79981887	NPC	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.15	1.08
38666	BRD-A79981887	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38890	BRD-A79981887	SKB	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.98	0.47
127373	BRD-A79981887	A375	10 uM	24 h	0.18	0.76	0.0	0.0	0.0	0.0
127493	BRD-A79981887	HT29	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.34
127540	BRD-A79981887	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.61
127628	BRD-A79981887	PC3	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127713	BRD-A79981887	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135353	BRD-A79981887	A549	0.74 uM	24 h	0.0	0.0	0.0	0.32	1.14	0.86
135384	BRD-A79981887	HELA	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135453	BRD-A79981887	MCF10A	0.25 uM	24 h	0.27	1.13	0.28	0.21	0.73	0.03
135483	BRD-A79981887	MCF??7.00	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135509	BRD-A79981887	THP1	2.22 uM	24 h	-0.2	-0.82	0.0	0.0	0.0	0.0

Summary