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CMap Candidate Details

Structure:
CMap ID: C03410
Pert ID: BRD-K13646352
Compound Name: midostaurin
Targets: FLT3|PRKCG
MoA: FLT3 inhibitor; KIT inhibitor; PKC inhibitor
SMILES: CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
49 BRD-K13646352 BJAB 2.5 uM 4 h 0.0 0.0 0.0 -0.24 -0.81 0.13
83 BRD-K13646352 HBL1 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
150 BRD-K13646352 K562 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
171 BRD-K13646352 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
213 BRD-K13646352 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
252 BRD-K13646352 OCILY10 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
283 BRD-K13646352 OCILY19 2.5 uM 24 h 0.25 1.06 0.18 0.32 1.13 0.85
329 BRD-K13646352 OCILY3 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
369 BRD-K13646352 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
403 BRD-K13646352 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
439 BRD-K13646352 TMD8 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2985 BRD-K13646352 HA1E 10 uM 6 h -0.24 -0.99 0.14 0.28 1.0 0.43
3334 BRD-K13646352 HCC515 10 uM 6 h 0.0 0.0 0.0 0.24 0.85 0.15
3727 BRD-K13646352 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42305 BRD-K13646352 ASC 10 uM 24 h -0.28 -1.17 0.5 0.29 1.02 0.47
42940 BRD-K13646352 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43497 BRD-K13646352 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43799 BRD-K13646352 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95558 BRD-K13646352 MCF??7.00 1.11 uM 24 h 0.21 0.88 0.01 -0.21 -0.7 0.03
95644 BRD-K13646352 U2OS 1.11 uM 24 h 0.0 0.0 0.0 -0.43 -1.44 15.35
97290 BRD-K13646352 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97366 BRD-K13646352 A375 3.33 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
116150 BRD-K13646352 HEPG2 3.33 uM 24 h -0.19 -0.77 0.0 -0.47 -1.59 15.65
122317 BRD-K13646352 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122363 BRD-K13646352 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
122419 BRD-K13646352 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130557 BRD-K13646352 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130668 BRD-K13646352 HELA 0.74 uM 24 h 0.25 1.06 0.18 -0.28 -0.95 0.42
130812 BRD-K13646352 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130837 BRD-K13646352 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).