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CMap Candidate Details

Structure:
CMap ID: C03411
Pert ID: BRD-K37270826
Compound Name: mifepristone
Targets: AR|NR1I2|NR3C1|PGR
MoA: glucocorticoid receptor antagonist; progesterone receptor antagonist
SMILES: CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2876 BRD-K37270826 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3189 BRD-K37270826 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.24
24431 BRD-K37270826 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25156 BRD-K37270826 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25505 BRD-K37270826 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44944 BRD-K37270826 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45242 BRD-K37270826 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45512 BRD-K37270826 HT29 10 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.39
45691 BRD-K37270826 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46698 BRD-K37270826 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90646 BRD-K37270826 HCT116 10 uM 24 h 0.23 0.94 0.06 -0.3 -1.0 0.55
90665 BRD-K37270826 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91422 BRD-K37270826 HUH7 8 uM 72 h 0.29 1.21 0.45 0.0 0.0 0.0
96137 BRD-K37270826 A549 10 uM 24 h 0.0 0.0 0.0 -0.3 -0.99 0.51
98892 BRD-K37270826 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99142 BRD-K37270826 NPC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.49
99896 BRD-K37270826 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).