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CMap Candidate Details

Structure:
CMap ID: C03417
Pert ID: BRD-K67080878
Compound Name: milrinone
Targets: PDE2A|PDE3A|PDE3B|PDE5A
MoA: phosphodiesterase inhibitor
SMILES: Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1946 BRD-K67080878 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2494 BRD-K67080878 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25037 BRD-K67080878 MCF??7.00 10 uM 24 h -0.3 -1.23 0.64 -0.19 -0.64 0.01
25261 BRD-K67080878 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42441 BRD-K67080878 ASC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
42756 BRD-K67080878 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43620 BRD-K67080878 NPC 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
43922 BRD-K67080878 PHH 10 uM 24 h 0.22 0.92 0.04 0.29 1.01 0.45
91377 BRD-K67080878 HUH7 15 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
96739 BRD-K67080878 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124629 BRD-K67080878 HA1E 0.04 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
124708 BRD-K67080878 HT29 1.11 uM 24 h -0.22 -0.91 0.05 -0.35 -1.17 1.14
124735 BRD-K67080878 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124815 BRD-K67080878 MDAMB231 1.11 uM 24 h 0.17 0.72 0.0 0.0 0.0 0.0
124899 BRD-K67080878 THP1 0.125 uM 24 h 0.33 1.36 0.97 0.0 0.0 0.0
124923 BRD-K67080878 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132705 BRD-K67080878 A549 0.08 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
132771 BRD-K67080878 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.26
132798 BRD-K67080878 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132886 BRD-K67080878 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).