CMap Candidate Details
Structure:
| CMap ID: | C03431 |
| Pert ID: | BRD-A64977602 |
| Compound Name: | mirtazapine |
| Targets: | ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|DRD1|DRD2|DRD3|DRD5|HRH1|HRH3|HTR2A|HTR2B|HTR2C|HTR3A|HTR7|OPRK1|SLC6A2|SLC6A3|SLC6A4 |
| MoA: | adrenergic receptor antagonist; serotonin receptor antagonist |
| SMILES: | CN1CCN2C(C1)c1ccccc1Cc1cccnc21 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 5538 | BRD-A64977602 | HCC515 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 5852 | BRD-A64977602 | HEPG2 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 25222 | BRD-A64977602 | PC3 | 10 uM | 6 h | 0.19 | 0.8 | 0.0 | -0.33 | -1.12 | 0.94 |
| 25479 | BRD-A64977602 | VCAP | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.31 | -1.05 | 0.71 |
| 39582 | BRD-A64977602 | ASC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 40707 | BRD-A64977602 | NEU | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.24 | -0.81 | 0.14 |
| 41007 | BRD-A64977602 | NPC | 10 uM | 24 h | -0.2 | -0.84 | 0.01 | -0.22 | -0.74 | 0.05 |
| 41329 | BRD-A64977602 | SKB | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 100268 | BRD-A64977602 | U2OS | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124579 | BRD-A64977602 | A375 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124617 | BRD-A64977602 | HA1E | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124660 | BRD-A64977602 | HELA | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.41 | -1.38 | 2.02 |
| 124694 | BRD-A64977602 | HT29 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124763 | BRD-A64977602 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.38 | -1.27 | 1.39 |
| 124799 | BRD-A64977602 | MDAMB231 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.21 | -0.7 | 0.03 |
| 132690 | BRD-A64977602 | A549 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.21 | 0.74 | 0.04 |
| 132756 | BRD-A64977602 | HEK293 | 0.01 uM | 24 h | 0.26 | 1.1 | 0.24 | 0.3 | 1.06 | 0.61 |
| 132835 | BRD-A64977602 | JURKAT | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132871 | BRD-A64977602 | MCF10A | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132932 | BRD-A64977602 | THP1 | 0.25 uM | 24 h | 0.25 | 1.05 | 0.17 | -0.27 | -0.9 | 0.28 |
| 132953 | BRD-A64977602 | YAPC | 0.01 uM | 24 h | 0.22 | 0.93 | 0.05 | 0.0 | 0.0 | 0.0 |