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CMap Candidate Details

Structure:
CMap ID: C03438
Pert ID: BRD-K21680192
Compound Name: mitoxantrone
Targets: TOP2A
MoA: topoisomerase inhibitor
SMILES: OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8 BRD-K21680192 NCIH2073 10 uM 24 h 0.0 0.0 0.0 0.4 1.43 2.2
16 BRD-K21680192 NCIH508 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25 BRD-K21680192 NCIH596 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
181 BRD-K21680192 KMS34 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
560 BRD-K21680192 HBL1 10 uM 4 h -0.2 -0.84 0.01 -0.38 -1.27 1.43
737 BRD-K21680192 NALM6 0.01 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.89
770 BRD-K21680192 OCILY19 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
813 BRD-K21680192 OCILY3 0.04 uM 24 h -0.23 -0.98 0.11 0.0 0.0 0.0
920 BRD-K21680192 THP1 0.01 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
944 BRD-K21680192 TMD8 0.04 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
52959 BRD-K21680192 HEPG2 2.5 uM 3 h 0.19 0.81 0.0 0.0 0.0 0.0
53569 BRD-K21680192 HUH7 2.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
53649 BRD-K21680192 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
84969 BRD-K21680192 A375 4 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
85061 BRD-K21680192 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
85260 BRD-K21680192 HCC515 4 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.62
87297 BRD-K21680192 BJAB 0.66 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87388 BRD-K21680192 K562 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87482 BRD-K21680192 MINO 0.04 uM 24 h 0.0 0.0 0.0 0.41 1.43 2.21
87590 BRD-K21680192 OCILY10 0.01 uM 24 h 0.0 0.0 0.0 -0.45 -1.5 15.35
87740 BRD-K21680192 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
88148 BRD-K21680192 VCAP 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90432 BRD-K21680192 HL60 10 uM 24 h 0.0 0.0 0.0 0.34 1.2 1.07
90599 BRD-K21680192 HCT116 0.125 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
92037 BRD-K21680192 BT20 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92154 BRD-K21680192 HS578T 0.04 uM 3 h 0.0 0.0 0.0 -0.29 -0.99 0.51
92178 BRD-K21680192 HT29 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92270 BRD-K21680192 MCF??7.00 10 uM 3 h -0.2 -0.85 0.01 0.0 0.0 0.0
92283 BRD-K21680192 MDAMB231 0.04 uM 24 h -0.27 -1.11 0.36 0.0 0.0 0.0
92387 BRD-K21680192 SKBR3 0.37 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92557 BRD-K21680192 HME1 0.37 uM 3 h 0.0 0.0 0.0 -0.41 -1.38 2.02
92654 BRD-K21680192 LNCAP 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92710 BRD-K21680192 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.99
92799 BRD-K21680192 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92951 BRD-K21680192 ASC 10 uM 24 h 0.0 0.0 0.0 0.4 1.43 2.2
93064 BRD-K21680192 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93468 BRD-K21680192 SKL 10 uM 24 h 0.0 0.0 0.0 0.44 1.55 2.32
94149 BRD-K21680192 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94815 BRD-K21680192 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97952 BRD-K21680192 P1A82 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
106172 BRD-K21680192 U2OS 20 uM 6 h 0.0 0.0 0.0 0.38 1.36 1.72
115701 BRD-K21680192 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119726 BRD-K21680192 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121521 BRD-K21680192 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129468 BRD-K21680192 HELA 0.74 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.2
136417 BRD-K21680192 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).