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CMap Candidate Details

Structure:
CMap ID: C03445
Pert ID: BRD-K18850819
Compound Name: MK-0752
Targets:
MoA: gamma secretase inhibitor
SMILES: OC(=O)CC[C@H]1CC[C@@](CC1)(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90873 BRD-K18850819 MCF10A 10 uM 3 h 0.0 0.0 0.0 0.34 1.22 1.15
96770 BRD-K18850819 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118492 BRD-K18850819 HCC515 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.91
118538 BRD-K18850819 HEPG2 10 uM 24 h -0.2 -0.84 0.01 -0.26 -0.89 0.27
118616 BRD-K18850819 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.3
120883 BRD-K18850819 A549 10 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
120899 BRD-K18850819 HA1E 3.33 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
120930 BRD-K18850819 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120982 BRD-K18850819 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121088 BRD-K18850819 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129091 BRD-K18850819 A375 0.74 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
129179 BRD-K18850819 HT29 2.22 uM 24 h 0.22 0.92 0.04 0.26 0.91 0.24
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).