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CMap Candidate Details

Structure:
CMap ID: C03447
Pert ID: BRD-K14175878
Compound Name: MK-0812
Targets: CCR2
MoA: CC chemokine receptor antagonist
SMILES: CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](C1)(C(C)C)C(=O)N1CCc2ncc(cc2C1)C(F)(F)F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122255 BRD-K14175878 A375 10 uM 24 h -0.33 -1.39 1.09 0.0 0.0 0.0
122298 BRD-K14175878 HA1E 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
122391 BRD-K14175878 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
122479 BRD-K14175878 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122517 BRD-K14175878 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130559 BRD-K14175878 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130628 BRD-K14175878 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130671 BRD-K14175878 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130710 BRD-K14175878 HT29 0.74 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
130742 BRD-K14175878 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130785 BRD-K14175878 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130815 BRD-K14175878 PC3 0.01 uM 24 h 0.19 0.77 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).