Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C03449
Pert ID: BRD-K54256913
Compound Name: MK-1775
Targets: WEE1
MoA: WEE1 kinase inhibitor
SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC=C)c3=O)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8956 BRD-K54256913 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9445 BRD-K54256913 AGS 10 uM 6 h 0.19 0.8 0.0 0.0 0.0 0.0
9751 BRD-K54256913 H1299 10 uM 6 h 0.24 1.02 0.12 0.0 0.0 0.0
10338 BRD-K54256913 HCC515 10 uM 6 h 0.22 0.9 0.02 -0.25 -0.83 0.17
11221 BRD-K54256913 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11512 BRD-K54256913 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11783 BRD-K54256913 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12072 BRD-K54256913 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12335 BRD-K54256913 NOMO1 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.74 0.05
12813 BRD-K54256913 SW480 10 uM 6 h 0.22 0.92 0.04 0.0 0.0 0.0
13298 BRD-K54256913 U937 10 uM 6 h 0.0 0.0 0.0 0.23 0.8 0.08
13637 BRD-K54256913 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91813 BRD-K54256913 HS578T 0.37 uM 6 h 0.18 0.74 0.0 -0.28 -0.96 0.43
91964 BRD-K54256913 SKBR3 2.22 uM 6 h 0.0 0.0 0.0 0.16 0.58 0.0
93635 BRD-K54256913 ASC 3.33 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
93691 BRD-K54256913 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93909 BRD-K54256913 HEPG2 3.33 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
93977 BRD-K54256913 HUVEC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94005 BRD-K54256913 JURKAT 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94083 BRD-K54256913 NEU 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94148 BRD-K54256913 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94214 BRD-K54256913 SHSY5Y 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94267 BRD-K54256913 SKL 3.33 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
94318 BRD-K54256913 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94363 BRD-K54256913 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117642 BRD-K54256913 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
124320 BRD-K54256913 HEK293 10 uM 24 h 0.3 1.27 0.58 0.0 0.0 0.0
124386 BRD-K54256913 HT29 0.125 uM 24 h -0.31 -1.27 0.74 -0.47 -1.57 15.65
132360 BRD-K54256913 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132391 BRD-K54256913 HA1E 0.25 uM 24 h 0.21 0.87 0.01 0.22 0.79 0.07
132446 BRD-K54256913 HELA 0.74 uM 24 h 0.24 1.0 0.11 -0.45 -1.51 15.35
132496 BRD-K54256913 MCF10A 0.74 uM 24 h -0.19 -0.8 0.0 -0.28 -0.93 0.36
132554 BRD-K54256913 MDAMB231 2.22 uM 24 h -0.22 -0.93 0.07 -0.43 -1.44 15.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).