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CMap Candidate Details

Structure:
CMap ID: C03451
Pert ID: BRD-K68065987
Compound Name: MK-2206
Targets: AKT1|AKT2|AKT3
MoA: AKT inhibitor
SMILES: NC1(CCC1)c1ccc(cc1)-c1nc2ccn3c(n[nH]c3=O)c2cc1-c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
498 BRD-K68065987 BJAB 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
536 BRD-K68065987 HBL1 10 uM 24 h 0.26 1.1 0.24 -0.28 -0.93 0.34
576 BRD-K68065987 K562 10 uM 24 h -0.22 -0.92 0.06 0.24 0.86 0.15
636 BRD-K68065987 KMS34 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
682 BRD-K68065987 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
729 BRD-K68065987 NALM6 10 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
764 BRD-K68065987 OCILY19 0.66 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.5
810 BRD-K68065987 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
871 BRD-K68065987 SKMEL5 10 uM 24 h 0.21 0.88 0.02 0.0 0.0 0.0
966 BRD-K68065987 TMD8 10 uM 4 h 0.22 0.91 0.03 0.0 0.0 0.0
9481 BRD-K68065987 AGS 10 uM 6 h -0.2 -0.83 0.0 -0.27 -0.89 0.27
9786 BRD-K68065987 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10568 BRD-K68065987 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11547 BRD-K68065987 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.36 1.26 1.29
11813 BRD-K68065987 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12105 BRD-K68065987 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.27 0.95 0.31
12364 BRD-K68065987 NOMO1 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.55
12947 BRD-K68065987 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13332 BRD-K68065987 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13661 BRD-K68065987 VCAP 10 uM 6 h -0.18 -0.76 0.0 0.34 1.2 1.06
91663 BRD-K68065987 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
92461 BRD-K68065987 BT20 3.33 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.71
92577 BRD-K68065987 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92663 BRD-K68065987 LNCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92729 BRD-K68065987 MCF10A 0.04 uM 3 h -0.23 -0.94 0.08 -0.29 -0.97 0.46
92788 BRD-K68065987 MDAMB231 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92848 BRD-K68065987 SKBR3 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
95401 BRD-K68065987 U2OS 10 uM 24 h -0.25 -1.06 0.26 -0.39 -1.32 1.71
96071 BRD-K68065987 HME1 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116674 BRD-K68065987 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116805 BRD-K68065987 HCC515 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.15
116848 BRD-K68065987 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116981 BRD-K68065987 PC3 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.4
126642 BRD-K68065987 A549 3.33 uM 24 h -0.26 -1.07 0.27 0.0 0.0 0.0
126683 BRD-K68065987 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126705 BRD-K68065987 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126759 BRD-K68065987 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134716 BRD-K68065987 HA1E 0.74 uM 24 h 0.22 0.92 0.04 0.21 0.73 0.03
134813 BRD-K68065987 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134840 BRD-K68065987 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134980 BRD-K68065987 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).