CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03453
Pert ID:	BRD-K56405753
Compound Name:	MK-2461
Targets:	FGFR1\|FGFR2\|FGFR3\|FLT1\|FLT3\|FLT4\|KDR\|MERTK\|MET\|MST1R\|NTRK1\|NTRK2\|PDGFRB
MoA:	FGFR inhibitor; VEGFR inhibitor
SMILES:	CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
123790	BRD-K56405753	A375	10 uM	24 h	0.19	0.78	0.0	-0.34	-1.16	1.11
123831	BRD-K56405753	A549	0.04 uM	24 h	0.25	1.04	0.15	-0.33	-1.12	0.94
123868	BRD-K56405753	HA1E	10 uM	24 h	0.22	0.92	0.04	-0.37	-1.24	1.3
123891	BRD-K56405753	HEK293	10 uM	24 h	0.26	1.1	0.24	-0.32	-1.07	0.76
123960	BRD-K56405753	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123991	BRD-K56405753	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124045	BRD-K56405753	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124173	BRD-K56405753	THP1	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.86	0.2
124226	BRD-K56405753	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132190	BRD-K56405753	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.42	1.47	2.24
132250	BRD-K56405753	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.34
132272	BRD-K56405753	MDAMB231	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132292	BRD-K56405753	PC3	2.22 uM	24 h	0.0	0.0	0.0	-0.38	-1.27	1.39

Summary