CMap Candidate Details
Structure:
| CMap ID: | C03458 |
| Pert ID: | BRD-K53665955 |
| Compound Name: | MK-5108 |
| Targets: | AURKA|AURKB|AURKC |
| MoA: | Aurora kinase inhibitor |
| SMILES: | OC(=O)[C@@]1(Cc2cccc(Nc3nccs3)n2)CC[C@@H](CC1)Oc1cccc(Cl)c1F |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 119437 | BRD-K53665955 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 119502 | BRD-K53665955 | HCC515 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 119539 | BRD-K53665955 | HEPG2 | 10 uM | 24 h | 0.24 | 1.01 | 0.11 | 0.0 | 0.0 | 0.0 |
| 119634 | BRD-K53665955 | PC3 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121565 | BRD-K53665955 | A375 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121607 | BRD-K53665955 | HA1E | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.24 | -0.81 | 0.13 |
| 121642 | BRD-K53665955 | HELA | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121684 | BRD-K53665955 | MCF??7.00 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129639 | BRD-K53665955 | HT29 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129731 | BRD-K53665955 | YAPC | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.29 | 1.01 | 0.46 |