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CMap Candidate Details

Structure:
CMap ID: C03484
Pert ID: BRD-K59317601
Compound Name: MLN0128
Targets: MTOR|PIK3CA|PIK3CD|PIK3CG
MoA: mTOR inhibitor
SMILES: CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92942 BRD-K59317601 ASC 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.26 1.39
93009 BRD-K59317601 CD34 3.33 uM 24 h 0.25 1.04 0.16 -0.28 -0.95 0.42
93096 BRD-K59317601 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93137 BRD-K59317601 HELA 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.66 0.01
93180 BRD-K59317601 HEPG2 3.33 uM 24 h -0.23 -0.97 0.11 -0.37 -1.25 1.35
93235 BRD-K59317601 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93324 BRD-K59317601 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
93425 BRD-K59317601 NPC 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
93515 BRD-K59317601 SKL 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123807 BRD-K59317601 A375 1.11 uM 24 h 0.25 1.03 0.13 -0.37 -1.24 1.31
123848 BRD-K59317601 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123969 BRD-K59317601 HT29 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
124016 BRD-K59317601 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124198 BRD-K59317601 THP1 1.11 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
124250 BRD-K59317601 YAPC 0.04 uM 24 h 0.0 0.0 0.0 -0.46 -1.55 15.35
132173 BRD-K59317601 HA1E 2.22 uM 24 h 0.34 1.41 1.03 -0.24 -0.8 0.11
132262 BRD-K59317601 MCF??7.00 0.01 uM 24 h 0.26 1.09 0.23 0.0 0.0 0.0
132278 BRD-K59317601 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132306 BRD-K59317601 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).