CMap Candidate Details
Structure:
| CMap ID: | C03486 |
| Pert ID: | BRD-K43410529 |
| Compound Name: | MLN2480 |
| Targets: | |
| MoA: | RAF inhibitor |
| SMILES: | C[C@@H](NC(=O)c1ncnc(N)c1Cl)c1ncc(s1)C(=O)Nc1cc(c(Cl)cn1)C(F)(F)F |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 123267 | BRD-K43410529 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123281 | BRD-K43410529 | HA1E | 10 uM | 24 h | -0.25 | -1.04 | 0.21 | 0.0 | 0.0 | 0.0 |
| 123295 | BRD-K43410529 | HEK293 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.27 | -0.9 | 0.29 |
| 123323 | BRD-K43410529 | HELA | 3.33 uM | 24 h | -0.19 | -0.81 | 0.0 | -0.41 | -1.4 | 2.02 |
| 123355 | BRD-K43410529 | HT29 | 3.33 uM | 24 h | 0.24 | 0.99 | 0.09 | 0.23 | 0.8 | 0.08 |
| 123376 | BRD-K43410529 | MCF10A | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123437 | BRD-K43410529 | PC3 | 0.125 uM | 24 h | -0.29 | -1.2 | 0.57 | 0.31 | 1.08 | 0.66 |
| 123472 | BRD-K43410529 | THP1 | 0.125 uM | 24 h | -0.22 | -0.94 | 0.08 | 0.24 | 0.84 | 0.13 |
| 131534 | BRD-K43410529 | A375 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.23 | -0.77 | 0.08 |
| 131744 | BRD-K43410529 | HUVEC | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.86 | 0.22 |
| 131799 | BRD-K43410529 | JURKAT | 0.25 uM | 24 h | -0.2 | -0.82 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131872 | BRD-K43410529 | MCF??7.00 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131904 | BRD-K43410529 | MDAMB231 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.99 | 0.51 |
| 131961 | BRD-K43410529 | YAPC | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |