CMap Candidate Details
Structure:
| CMap ID: | C03491 |
| Pert ID: | BRD-K64835161 |
| Compound Name: | ML167 |
| Targets: | CLK4|DYRK1B |
| MoA: | CLK inhibitor; DYRK inhibitor |
| SMILES: | Cc1ccc(CNc2ncnc3ccc(cc23)-c2ccc(CO)o2)o1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 22039 | BRD-K64835161 | A375 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.22 | -0.76 | 0.07 |
| 22318 | BRD-K64835161 | A549 | 10 uM | 6 h | -0.28 | -1.15 | 0.44 | 0.0 | 0.0 | 0.0 |
| 23613 | BRD-K64835161 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.36 | -1.22 | 1.24 |
| 24019 | BRD-K64835161 | PC3 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.4 | -1.35 | 2.02 |
| 24188 | BRD-K64835161 | VCAP | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 115152 | BRD-K64835161 | U2OS | 20 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.33 | -1.11 | 0.92 |
| 118775 | BRD-K64835161 | HA1E | 3.33 uM | 24 h | 0.22 | 0.91 | 0.03 | -0.32 | -1.07 | 0.76 |
| 118815 | BRD-K64835161 | HCC515 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 118858 | BRD-K64835161 | HEPG2 | 10 uM | 24 h | -0.22 | -0.9 | 0.05 | 0.25 | 0.87 | 0.17 |
| 118900 | BRD-K64835161 | HT29 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.3 | 1.57 |